CardioFocus was involved in a recent study of a visually guided laser ablation (VGLA) catheter. New catheter designs are in development to address the technical difficulty with achieving pulmonary vein (PV) isolation in the treatment of patients with paroxysmal atrial fibrillation (PAF). The visually-guided laser ablation (VGLA) catheter enables an operator to visualize target tissue for ablation, and then use the laser for point-to-point circumferential ablation. Single center studies demonstrated favorable safety and efficacy. Another study, including the first 200 PAF patients treated with the VGLA, sought to determine the multicenter feasibility, efficacy, and safety of performing PV isolation using the VGLA catheter. In this multicenter experience, PV isolation can be achieved in virtually all patients using a single VGLA catheter with an efficacy similar to radiofrequency ablation. For a full description of this issue, please visit http://bit.ly/11rArF9.